Detailed information of TA system TA250537

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1633225..1633804
• Replicon: chromosome
• Accession: NZ_CP100428
• Organism: Staphylococcus aureus strain RMSA24

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: NLG45_RS08255
• Protein ID: WP_001025401.1
• Coordinates: 1633559..1633804 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1633225..1633590 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NLG45_RS08215 (NLG45_08215)	1629970..1630524	-	555	WP_000647288.1	DUF2815 family protein	-
NLG45_RS08220 (NLG45_08220)	1630551..1631717	-	1167	WP_031883894.1	DUF2800 domain-containing protein	-
NLG45_RS08225 (NLG45_08225)	1631714..1632076	-	363	WP_031775157.1	hypothetical protein	-
NLG45_RS08230 (NLG45_08230)	1632091..1632414	-	324	WP_000174994.1	hypothetical protein	-
NLG45_RS08235 (NLG45_08235)	1632493..1632654	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
NLG45_RS08240 (NLG45_08240)	1632667..1632930	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
NLG45_RS08245 (NLG45_08245)	1632955..1633170	-	216	WP_001097552.1	hypothetical protein	-
NLG45_RS08250 (NLG45_08250)	1633225..1633590	+	366	WP_001128433.1	hypothetical protein	Antitoxin
NLG45_RS08255 (NLG45_08255)	1633559..1633804	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
NLG45_RS08260 (NLG45_08260)	1633860..1634069	+	210	WP_000642492.1	hypothetical protein	-
NLG45_RS08265 (NLG45_08265)	1634059..1634202	-	144	WP_000939498.1	hypothetical protein	-
NLG45_RS08270 (NLG45_08270)	1634231..1635007	-	777	WP_031914835.1	Rha family transcriptional regulator	-
NLG45_RS08275 (NLG45_08275)	1635046..1635255	-	210	WP_001114715.1	helix-turn-helix transcriptional regulator	-
NLG45_RS08280 (NLG45_08280)	1635418..1635744	+	327	WP_000455972.1	helix-turn-helix transcriptional regulator	-
NLG45_RS08285 (NLG45_08285)	1635766..1636224	+	459	WP_113532524.1	toxin	-
NLG45_RS08290 (NLG45_08290)	1636242..1636676	+	435	WP_000755721.1	hypothetical protein	-
NLG45_RS08295 (NLG45_08295)	1636705..1637100	+	396	WP_000449655.1	hypothetical protein	-
NLG45_RS08300 (NLG45_08300)	1637298..1637699	-	402	WP_223250915.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh / geh	1593456..1649804	56348

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T250537 WP_001025401.1 NZ_CP100428:c1633804-1633559 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT250537 NZ_CP100428:1633225-1633590 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin