25052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 1648453..1649801 Replicon chromosome
Accession NC_014920
Organism Haemophilus influenzae F3031

Toxin (Protein)


Gene name HipT Uniprot ID E7A6T7
Locus tag HIBPF_RS08305 Protein ID WP_013526379.1
Coordinates 1648770..1649801 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID E7A6T6
Locus tag HIBPF_RS08300 Protein ID WP_013526378.1
Coordinates 1648453..1648773 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HIBPF_RS08260 1643683..1643961 + 279 WP_005661211.1 cell division protein FtsB -
HIBPF_RS08265 1643961..1644638 + 678 WP_006995250.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
HIBPF_RS08270 1644635..1645111 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
HIBPF_RS10600 1645181..1645348 - 168 WP_006995248.1 hypothetical protein -
HIBPF_RS08275 1645607..1646041 - 435 WP_013526377.1 D-tyrosyl-tRNA(Tyr) deacylase -
HIBPF_RS08280 1646038..1646478 - 441 WP_005667635.1 FMN-binding protein MioC -
HIBPF_RS08285 1646575..1646793 - 219 WP_005650820.1 cell division protein ZapB -
HIBPF_RS08290 1646955..1647956 + 1002 WP_005690169.1 class II fructose-bisphosphatase -
HIBPF_RS08295 1648157..1648465 + 309 WP_005661200.1 helix-turn-helix domain-containing protein -
HIBPF_RS08300 1648453..1648773 + 321 WP_013526378.1 type II toxin-antitoxin system HipA family toxin Antitoxin
HIBPF_RS08305 1648770..1649801 + 1032 WP_013526379.1 type II toxin-antitoxin system HipA family toxin Toxin
HIBPF_RS08310 1649884..1651542 - 1659 WP_013526380.1 ABC transporter ATP-binding protein/permease -
HIBPF_RS08315 1651535..1653280 - 1746 WP_013526381.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39685.29 Da        Isoelectric Point: 6.7800

>T25052 WP_013526379.1 NC_014920:1648770-1649801 [Haemophilus influenzae F3031]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPGEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREESNATLAKGFNTQYGEYIGDDFVEFGANIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T25052 NC_014920:1648770-1649801 [Haemophilus influenzae F3031]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGGAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAGCGTGTTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGCGCGAGAAGAAAGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATAGGCGATGATTTTGTCGAGTTTGGGGCAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12486.15 Da        Isoelectric Point: 6.3254

>AT25052 WP_013526378.1 NC_014920:1648453-1648773 [Haemophilus influenzae F3031]
MRNLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT25052 NC_014920:1648453-1648773 [Haemophilus influenzae F3031]
ATGCGCAATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C2QYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R0D9

References