Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3699291..3699966 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZ581_RS17425 Protein ID WP_062937994.1
Coordinates 3699291..3699590 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ581_RS17430 Protein ID WP_032654721.1
Coordinates 3699601..3699966 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS17415 (LZ581_17415) 3695668..3697860 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
LZ581_RS17420 (LZ581_17420) 3697841..3699040 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
LZ581_RS17425 (LZ581_17425) 3699291..3699590 + 300 WP_062937994.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ581_RS17430 (LZ581_17430) 3699601..3699966 + 366 WP_032654721.1 HigA family addiction module antitoxin Antitoxin
LZ581_RS17435 (LZ581_17435) 3699993..3701174 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
LZ581_RS17440 (LZ581_17440) 3701195..3702082 - 888 WP_015571641.1 LysR family transcriptional regulator -
LZ581_RS17445 (LZ581_17445) 3702180..3702782 + 603 WP_032654728.1 short chain dehydrogenase -
LZ581_RS17450 (LZ581_17450) 3702779..3703510 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-71)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11658.30 Da        Isoelectric Point: 9.6776

>T250507 WP_062937994.1 NZ_CP100388:3699291-3699590 [Enterobacter hormaechei subsp. steigerwaltii]
MINHFRDQWFEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13731.81 Da        Isoelectric Point: 9.5936

>AT250507 WP_032654721.1 NZ_CP100388:3699601-3699966 [Enterobacter hormaechei subsp. steigerwaltii]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKLGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References