Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3002040..3002700 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q4X0
Locus tag LZ581_RS14240 Protein ID WP_017383312.1
Coordinates 3002347..3002700 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag LZ581_RS14235 Protein ID WP_017383313.1
Coordinates 3002040..3002342 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS14220 (LZ581_14220) 2998214..2999539 + 1326 WP_017383315.1 SidA/IucD/PvdA family monooxygenase -
LZ581_RS14225 (LZ581_14225) 2999566..3001755 + 2190 WP_032654151.1 TonB-dependent siderophore receptor -
LZ581_RS14235 (LZ581_14235) 3002040..3002342 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
LZ581_RS14240 (LZ581_14240) 3002347..3002700 - 354 WP_017383312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZ581_RS14245 (LZ581_14245) 3002891..3003841 - 951 WP_017383311.1 HTH-type transcriptional regulator Cbl -
LZ581_RS14250 (LZ581_14250) 3003938..3004855 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
LZ581_RS14260 (LZ581_14260) 3005387..3006319 - 933 WP_252031641.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13537.37 Da        Isoelectric Point: 9.9538

>T250506 WP_017383312.1 NZ_CP100388:c3002700-3002347 [Enterobacter hormaechei subsp. steigerwaltii]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT250506 WP_017383313.1 NZ_CP100388:c3002342-3002040 [Enterobacter hormaechei subsp. steigerwaltii]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q4X0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References