Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1224542..1225269 Replicon chromosome
Accession NZ_CP100388
Organism Enterobacter hormaechei subsp. steigerwaltii strain VKH10

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q486
Locus tag LZ581_RS05770 Protein ID WP_033486526.1
Coordinates 1224958..1225269 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZ581_RS05765 Protein ID WP_045907165.1
Coordinates 1224542..1224961 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZ581_RS05755 (LZ581_05755) 1222372..1223493 - 1122 WP_015571201.1 YbdK family carboxylate-amine ligase -
LZ581_RS05760 (LZ581_05760) 1223599..1224489 + 891 WP_033486528.1 oxidoreductase -
LZ581_RS05765 (LZ581_05765) 1224542..1224961 - 420 WP_045907165.1 helix-turn-helix domain-containing protein Antitoxin
LZ581_RS05770 (LZ581_05770) 1224958..1225269 - 312 WP_033486526.1 type II toxin-antitoxin system HigB family toxin Toxin
LZ581_RS05775 (LZ581_05775) 1225734..1226816 - 1083 WP_128771668.1 LysR family transcriptional regulator -
LZ581_RS05780 (LZ581_05780) 1226821..1227312 + 492 WP_128771667.1 GNAT family N-acetyltransferase -
LZ581_RS05785 (LZ581_05785) 1227407..1228864 + 1458 WP_058689341.1 amino acid permease -
LZ581_RS05790 (LZ581_05790) 1229090..1229608 - 519 WP_058688860.1 N-acetyltransferase -
LZ581_RS05795 (LZ581_05795) 1229635..1230096 - 462 WP_048229285.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(6-137)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12506.30 Da        Isoelectric Point: 9.9435

>T250499 WP_033486526.1 NZ_CP100388:c1225269-1224958 [Enterobacter hormaechei subsp. steigerwaltii]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLTDYYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15419.46 Da        Isoelectric Point: 4.5849

>AT250499 WP_045907165.1 NZ_CP100388:c1224961-1224542 [Enterobacter hormaechei subsp. steigerwaltii]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVDMLTDKIDKYENASPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q486

Antitoxin

Source ID Structure

References