Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2079972..2080491 Replicon chromosome
Accession NZ_CP100338
Organism Streptococcus suis strain STC80

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NKZ64_RS10380 Protein ID WP_013730620.1
Coordinates 2079972..2080229 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NKZ64_RS10385 Protein ID WP_002939010.1
Coordinates 2080231..2080491 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ64_RS10365 (NKZ64_10365) 2076442..2078172 - 1731 WP_024417308.1 membrane protein -
NKZ64_RS10370 (NKZ64_10370) 2078536..2079408 - 873 WP_024393352.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NKZ64_RS10375 (NKZ64_10375) 2079428..2079958 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NKZ64_RS10380 (NKZ64_10380) 2079972..2080229 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NKZ64_RS10385 (NKZ64_10385) 2080231..2080491 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NKZ64_RS10390 (NKZ64_10390) 2080567..2081022 - 456 WP_024417307.1 8-oxo-dGTP diphosphatase -
NKZ64_RS10395 (NKZ64_10395) 2081027..2081395 - 369 WP_024417306.1 hypothetical protein -
NKZ64_RS10400 (NKZ64_10400) 2081388..2081957 - 570 WP_024417305.1 ribonuclease M5 -
NKZ64_RS10405 (NKZ64_10405) 2081941..2082723 - 783 WP_024417304.1 TatD family hydrolase -
NKZ64_RS10410 (NKZ64_10410) 2082830..2082967 - 138 WP_002939016.1 50S ribosomal protein L34 -
NKZ64_RS10415 (NKZ64_10415) 2083135..2084130 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NKZ64_RS10420 (NKZ64_10420) 2084150..2084962 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NKZ64_RS10425 (NKZ64_10425) 2084946..2085305 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T250480 WP_013730620.1 NZ_CP100338:c2080229-2079972 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T250480 NZ_CP100338:c2080229-2079972 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACATTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT250480 WP_002939010.1 NZ_CP100338:c2080491-2080231 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT250480 NZ_CP100338:c2080491-2080231 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References