Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2077797..2078316 Replicon chromosome
Accession NZ_CP100336
Organism Streptococcus suis strain STC81

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag NKZ66_RS10365 Protein ID WP_013730620.1
Coordinates 2077797..2078054 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag NKZ66_RS10370 Protein ID WP_002939010.1
Coordinates 2078056..2078316 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKZ66_RS10350 (NKZ66_10350) 2074267..2075997 - 1731 WP_024417308.1 membrane protein -
NKZ66_RS10355 (NKZ66_10355) 2076361..2077233 - 873 WP_024393352.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
NKZ66_RS10360 (NKZ66_10360) 2077253..2077783 - 531 WP_009910909.1 DUF1697 domain-containing protein -
NKZ66_RS10365 (NKZ66_10365) 2077797..2078054 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
NKZ66_RS10370 (NKZ66_10370) 2078056..2078316 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NKZ66_RS10375 (NKZ66_10375) 2078392..2078847 - 456 WP_024417307.1 8-oxo-dGTP diphosphatase -
NKZ66_RS10380 (NKZ66_10380) 2078852..2079220 - 369 WP_024417306.1 hypothetical protein -
NKZ66_RS10385 (NKZ66_10385) 2079213..2079782 - 570 WP_024417305.1 ribonuclease M5 -
NKZ66_RS10390 (NKZ66_10390) 2079766..2080548 - 783 WP_024417304.1 TatD family hydrolase -
NKZ66_RS10395 (NKZ66_10395) 2080655..2080792 - 138 WP_002939016.1 50S ribosomal protein L34 -
NKZ66_RS10400 (NKZ66_10400) 2080960..2081955 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
NKZ66_RS10405 (NKZ66_10405) 2081975..2082787 - 813 WP_012027897.1 YidC/Oxa1 family membrane protein insertase -
NKZ66_RS10410 (NKZ66_10410) 2082771..2083130 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T250474 WP_013730620.1 NZ_CP100336:c2078054-2077797 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT250474 WP_002939010.1 NZ_CP100336:c2078316-2078056 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References