Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 763943..764718 Replicon chromosome
Accession NZ_CP100308
Organism Klebsiella pneumoniae strain 1021

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag NKY02_RS03850 Protein ID WP_004150910.1
Coordinates 764233..764718 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NKY02_RS03845 Protein ID WP_004150912.1
Coordinates 763943..764236 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKY02_RS03825 (759151) 759151..759753 - 603 WP_002916735.1 short chain dehydrogenase -
NKY02_RS03830 (759851) 759851..760762 + 912 WP_004188550.1 LysR family transcriptional regulator -
NKY02_RS03835 (760763) 760763..761911 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
NKY02_RS03840 (761922) 761922..763298 - 1377 WP_004217775.1 cystathionine beta-synthase -
NKY02_RS03845 (763943) 763943..764236 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NKY02_RS03850 (764233) 764233..764718 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
NKY02_RS03855 (765422) 765422..766015 + 594 WP_004188553.1 hypothetical protein -
NKY02_RS03860 (766112) 766112..766328 + 217 Protein_759 transposase -
NKY02_RS03870 (767006) 767006..767719 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 766112..766264 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T250407 WP_004150910.1 NZ_CP100308:764233-764718 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT250407 WP_004150912.1 NZ_CP100308:763943-764236 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References