Detailed information of TA system TA025038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2143387..2143997
• Replicon: chromosome
• Accession: NC_014844
• Organism: Desulfovibrio aespoeensis Aspo-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: E6VQW8
• Locus tag: DAES_RS09780
• Protein ID: WP_013514862.1
• Coordinates: 2143387..2143665 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DAES_RS17340
• Protein ID: WP_041271729.1
• Coordinates: 2143677..2143997 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAES_RS09755	2138941..2139462	+	522	WP_013514858.1	hypothetical protein	-
DAES_RS09760	2139477..2140040	+	564	WP_013514859.1	arylesterase	-
DAES_RS09765	2140037..2140732	-	696	WP_173358454.1	VTT domain-containing protein	-
DAES_RS09770	2140879..2142564	+	1686	WP_013514861.1	YcaO-like family protein	-
DAES_RS09780	2143387..2143665	+	279	WP_013514862.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAES_RS17340	2143677..2143997	+	321	WP_041271729.1	HigA family addiction module antidote protein	Antitoxin
DAES_RS09790	2144406..2145463	-	1058	Protein_1929	IS3 family transposase	-
DAES_RS17630	2145541..2145741	+	201	WP_157864842.1	hypothetical protein	-
DAES_RS09800	2145863..2146366	+	504	WP_013514864.1	hypothetical protein	-
DAES_RS09810	2146751..2147191	+	441	WP_013514866.1	DUF134 domain-containing protein	-
DAES_RS09820	2147422..2147874	+	453	WP_083808696.1	NifB/NifX family molybdenum-iron cluster-binding protein	-
DAES_RS09825	2147871..2148755	+	885	WP_013514868.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2145197..2145463	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (3-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-95)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10332.64 Da
• Isoelectric Point: 10.2226

>T25038 WP_013514862.1 NC_014844:2143387-2143665 [Pseudodesulfovibrio aespoeensis Aspo-2]
VIKSFSHKGLEVFFRSGSTKGIQAKHADRLGRILDRLDAAAEARDMNAPGYDLHPLKGNLAGHWSVKVSGNWRVTFRMDN
GNAHIVNYQDYH

Nucleotide

• Length: 279 bp

>T25038 NC_014844:2143387-2143665 [Pseudodesulfovibrio aespoeensis Aspo-2]
GTGATCAAGAGCTTTTCACACAAAGGGCTTGAAGTCTTTTTCAGGAGCGGGAGCACCAAGGGCATACAGGCCAAGCACGC
GGACAGGCTCGGCAGGATATTGGACCGACTGGACGCCGCCGCCGAGGCCCGAGACATGAACGCGCCGGGCTACGATCTTC
ACCCTTTGAAAGGGAATCTGGCCGGGCATTGGTCCGTGAAGGTATCCGGCAACTGGCGTGTGACCTTCCGCATGGACAAT
GGCAACGCCCACATCGTGAACTATCAGGACTACCACTAG

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11751.43 Da
• Isoelectric Point: 10.0759

>AT25038 WP_041271729.1 NC_014844:2143677-2143997 [Pseudodesulfovibrio aespoeensis Aspo-2]
MGTTTRKPTHPGAIIRQDYMEPLSLTVTGLAAHLGVSRKHLSQILHERASVTSGLALRLARAFDTTADLWLNLQRKRDLW
EAERDTPGLENVEPLPGLQGMGRDAR

Nucleotide

• Length: 321 bp

>AT25038 NC_014844:2143677-2143997 [Pseudodesulfovibrio aespoeensis Aspo-2]
ATGGGCACCACAACCCGCAAGCCGACCCATCCGGGGGCAATCATTCGCCAGGACTACATGGAGCCGCTGTCTTTGACCGT
CACGGGTCTGGCGGCACACTTGGGTGTCAGCCGCAAGCATCTTTCCCAGATTCTCCATGAAAGGGCCAGCGTCACATCCG
GCCTTGCCCTTCGCCTTGCCAGGGCTTTCGATACCACCGCCGATCTTTGGCTCAACCTCCAGCGCAAGCGCGACCTGTGG
GAAGCCGAGCGGGACACGCCCGGCCTTGAAAACGTCGAGCCATTGCCAGGGTTGCAGGGGATGGGCAGGGACGCACGATA
G

Structures

Toxin

• AlphaFold DB: E6VQW8