Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2564752..2565345 Replicon chromosome
Accession NZ_CP100128
Organism Chromobacterium sp. IIBBL 290-4

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag NKT35_RS24045 Protein ID WP_256493448.1
Coordinates 2564752..2565030 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NKT35_RS11775 Protein ID WP_254293123.1
Coordinates 2565043..2565345 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NKT35_RS11745 (NKT35_11745) 2562242..2562544 - 303 WP_254293111.1 BrnA antitoxin family protein -
NKT35_RS11750 (NKT35_11750) 2562555..2562863 - 309 WP_254293113.1 hypothetical protein -
NKT35_RS11755 (NKT35_11755) 2563069..2563410 - 342 WP_254293115.1 hypothetical protein -
NKT35_RS11760 (NKT35_11760) 2563407..2563889 - 483 WP_254293117.1 hypothetical protein -
NKT35_RS11765 (NKT35_11765) 2563886..2564260 - 375 WP_254293119.1 hypothetical protein -
NKT35_RS24045 2564752..2565030 + 279 WP_256493448.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NKT35_RS11775 (NKT35_11775) 2565043..2565345 + 303 WP_254293123.1 HigA family addiction module antitoxin Antitoxin
NKT35_RS11780 (NKT35_11780) 2566549..2567295 - 747 WP_254293125.1 plasmid recombination protein -
NKT35_RS11785 (NKT35_11785) 2567399..2568112 - 714 WP_254293127.1 phage antirepressor N-terminal domain-containing protein -
NKT35_RS11790 (NKT35_11790) 2568109..2568417 - 309 WP_254293129.1 helix-turn-helix domain-containing protein -
NKT35_RS11795 (NKT35_11795) 2568429..2568650 - 222 WP_254293131.1 AlpA family phage regulatory protein -
NKT35_RS11800 (NKT35_11800) 2568733..2569386 - 654 WP_254293132.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2559007..2569386 10379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10437.90 Da        Isoelectric Point: 5.8219

>T250259 WP_256493448.1 NZ_CP100128:2564752-2565030 [Chromobacterium sp. IIBBL 290-4]
MIRSFRCIDTQALFAGESVPSLANIRAVAERKLQMIASACTVGFLRSPPGNRLEALKGDREGQFSIRINDQWRICFRFED
GDAFDVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11096.85 Da        Isoelectric Point: 9.6576

>AT250259 WP_254293123.1 NZ_CP100128:2565043-2565345 [Chromobacterium sp. IIBBL 290-4]
MTIKNGMRPIHPGEILREDYLTPLNMTPHALSLALHIPASRVNDIVRGRRGITVDTAMRLARYFGGDAQSWLNLQTVYEL
KQAAGALETKISQEITPLTA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References