Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2188456..2188892 Replicon chromosome
Accession NC_014836
Organism Desulfurispirillum indicum S5

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SELIN_RS14770 Protein ID WP_156788059.1
Coordinates 2188749..2188892 (-) Length 48 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SELIN_RS10250 Protein ID WP_013506598.1
Coordinates 2188456..2188749 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SELIN_RS10225 2183468..2184010 + 543 WP_041726888.1 NADP oxidoreductase -
SELIN_RS15260 2184446..2184871 + 426 WP_013506593.1 copper chaperone Copz family protein -
SELIN_RS14765 2185251..2185649 + 399 WP_013506594.1 GFA family protein -
SELIN_RS10230 2185969..2186970 + 1002 WP_013506595.1 hypothetical protein -
SELIN_RS10235 2187010..2187252 - 243 WP_013506596.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SELIN_RS15265 2187722..2187952 + 231 WP_013506597.1 hypothetical protein -
SELIN_RS15270 2187949..2188113 + 165 WP_198007086.1 hypothetical protein -
SELIN_RS15275 2188117..2188314 + 198 WP_198007162.1 PIN domain-containing protein -
SELIN_RS10250 2188456..2188749 - 294 WP_013506598.1 HigA family addiction module antidote protein Antitoxin
SELIN_RS14770 2188749..2188892 - 144 WP_156788059.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SELIN_RS10255 2189017..2189713 + 697 Protein_1980 IS5 family transposase -
SELIN_RS10265 2189774..2190947 + 1174 Protein_1981 IS3 family transposase -
SELIN_RS10270 2191011..2191553 + 543 WP_083806011.1 IS3 family transposase -
SELIN_RS10275 2191611..2192612 + 1002 WP_013506600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-47)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-85)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5365.03 Da        Isoelectric Point: 8.6240

>T25016 WP_156788059.1 NC_014836:c2188892-2188749 [Desulfurispirillum indicum S5]
MDLPGLALHELKGSRKGAWSVKVSGNWRVTFRFTGNNAEIVNYEDYH

Download         Length: 144 bp

>T25016 NC_014836:c2188892-2188749 [Desulfurispirillum indicum S5]
ATGGATTTACCGGGACTTGCTCTTCACGAGCTGAAAGGCAGTCGCAAAGGTGCCTGGTCTGTCAAGGTGAGTGGGAACTG
GAGAGTCACCTTTCGCTTCACCGGAAACAATGCAGAAATTGTAAACTATGAGGATTACCACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10789.58 Da        Isoelectric Point: 9.0756

>AT25016 WP_013506598.1 NC_014836:c2188749-2188456 [Desulfurispirillum indicum S5]
MSMHNPAHPGAILKELILELGITVTDAAAHLCVSRKTLSKILNGRGAITTDMALRLEMVFGKPSADHWLRLQSAYDLWQA
RNNRQAVHVVPYEMNLA

Download         Length: 294 bp

>AT25016 NC_014836:c2188749-2188456 [Desulfurispirillum indicum S5]
ATGAGCATGCATAACCCCGCCCATCCGGGCGCAATACTCAAAGAACTTATTTTGGAACTGGGCATCACCGTGACTGATGC
CGCAGCGCATCTTTGTGTCAGCCGTAAGACGCTTTCAAAAATCCTCAATGGACGCGGTGCAATTACTACAGACATGGCCC
TGCGCCTGGAGATGGTTTTCGGGAAACCCTCAGCCGATCATTGGCTCAGGCTGCAAAGTGCCTATGACCTGTGGCAGGCG
AGAAATAACCGCCAGGCCGTGCACGTTGTACCCTACGAAATGAATCTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References