Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2792504..2793158 Replicon chromosome
Accession NZ_CP099975
Organism Halomonas sp. Y3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NHL60_RS13285 Protein ID WP_253444178.1
Coordinates 2792504..2792845 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NHL60_RS13290 Protein ID WP_253444181.1
Coordinates 2792856..2793158 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL60_RS13255 2787604..2789082 - 1479 WP_253444162.1 glutamate--tRNA ligase -
NHL60_RS13260 2789231..2789971 + 741 WP_253444165.1 SDR family NAD(P)-dependent oxidoreductase -
NHL60_RS13265 2790094..2790684 + 591 WP_253444167.1 helix-turn-helix transcriptional regulator -
NHL60_RS13270 2790690..2791277 - 588 WP_253444170.1 hypothetical protein -
NHL60_RS13275 2791347..2791733 - 387 WP_253444172.1 TraR/DksA C4-type zinc finger protein -
NHL60_RS13280 2791828..2792067 - 240 WP_253444175.1 hypothetical protein -
NHL60_RS13285 2792504..2792845 + 342 WP_253444178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NHL60_RS13290 2792856..2793158 + 303 WP_253444181.1 XRE family transcriptional regulator Antitoxin
NHL60_RS13295 2793155..2793382 + 228 WP_253444184.1 hypothetical protein -
NHL60_RS13300 2793474..2794484 + 1011 WP_253444187.1 tRNA dihydrouridine(20/20a) synthase DusA -
NHL60_RS13305 2794495..2795526 - 1032 WP_253444190.1 succinylglutamate desuccinylase/aspartoacylase family protein -
NHL60_RS13310 2795686..2796303 + 618 WP_253444193.1 TetR family transcriptional regulator -
NHL60_RS13315 2796333..2797088 - 756 WP_253444196.1 enoyl-CoA hydratase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(20-89)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13194.96 Da        Isoelectric Point: 6.4688

>T250021 WP_253444178.1 NZ_CP099975:2792504-2792845 [Halomonas sp. Y3]
MWQIEQTSTFEEWYFSLDDTDRENVLAALLMLRERGPMLPRPHADTVNGSQYRNMKELRIQSQGRPLRAFFAFDPRRTGI
VLCAGDKTGNKRFYDDLIPVADREYAAHLESLK

Download         Length: 342 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11115.86 Da        Isoelectric Point: 5.7642

>AT250021 WP_253444181.1 NZ_CP099975:2792856-2793158 [Halomonas sp. Y3]
MTRTLDQLLASERPEVVSRAKEKADEMLLELRLAEVRRLVEMTQAEMAEALGVKQPTIAGMEKGGQDLRLSSLKRYVEAI
GGKVRLDIELPDGTHHGFSV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References