Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4488652..4489254 Replicon chromosome
Accession NZ_CP099973
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain SE006

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag NHL55_RS21805 Protein ID WP_001159635.1
Coordinates 4488943..4489254 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NHL55_RS21800 Protein ID WP_000362050.1
Coordinates 4488652..4488942 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NHL55_RS21785 (4486145) 4486145..4487047 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
NHL55_RS21790 (4487044) 4487044..4487679 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NHL55_RS21795 (4487676) 4487676..4488605 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
NHL55_RS21800 (4488652) 4488652..4488942 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
NHL55_RS21805 (4488943) 4488943..4489254 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
NHL55_RS21810 (4489472) 4489472..4490401 + 930 WP_001127705.1 alpha/beta hydrolase -
NHL55_RS21815 (4490487) 4490487..4490798 + 312 WP_000558168.1 type II toxin-antitoxin system HigB family toxin -
NHL55_RS21820 (4490795) 4490795..4491241 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
NHL55_RS21825 (4491256) 4491256..4492197 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NHL55_RS21830 (4492242) 4492242..4492679 - 438 WP_000560968.1 D-aminoacyl-tRNA deacylase -
NHL55_RS21835 (4492676) 4492676..4493548 - 873 WP_000921423.1 virulence factor BrkB family protein -
NHL55_RS21840 (4493542) 4493542..4494141 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T250014 WP_001159635.1 NZ_CP099973:c4489254-4488943 [Salmonella enterica subsp. enterica serovar Enteritidis]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT250014 WP_000362050.1 NZ_CP099973:c4488942-4488652 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References