Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-couple_hipB
Location 1143821..1144497 Replicon chromosome
Accession NC_014815
Organism Micromonospora sp. L5

Toxin (Protein)


Gene name higB Uniprot ID A0A1C6T5J3
Locus tag ML5_RS05750 Protein ID WP_013474046.1
Coordinates 1144135..1144497 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ML5_RS05745 Protein ID WP_013284102.1
Coordinates 1143821..1144138 (-) Length 106 a.a.

Genomic Context

ML5_RS05705ML5_RS05710ML5_RS05715ML5_RS05720ML5_RS05730ML5_RS05735ML5_RS05740ML5_RS05755ML5_RS05760ML5_RS05765ML5_RS05770ML5_RS05775ML5_RS05725ML5_RS05745ML5_RS05750
Location: 1139016..1139651 (636 bp)
Type: Others
Protein ID: WP_013284094.1
Location: 1139675..1140232 (558 bp)
Type: Others
Protein ID: WP_013284095.1
Location: 1140234..1140743 (510 bp)
Type: Others
Protein ID: WP_013284096.1
Location: 1140786..1141715 (930 bp)
Type: Others
Protein ID: WP_013474042.1
Location: 1142098..1142385 (288 bp)
Type: Others
Protein ID: WP_013474043.1
Location: 1142450..1142782 (333 bp)
Type: Others
Protein ID: WP_030271259.1
Location: 1142779..1143738 (960 bp)
Type: Others
Protein ID: WP_013474045.1
Location: 1144675..1145415 (741 bp)
Type: Others
Protein ID: WP_013474047.1
Location: 1145435..1146148 (714 bp)
Type: Others
Protein ID: WP_013474048.1
Location: 1146169..1146900 (732 bp)
Type: Others
Protein ID: WP_013474049.1
Location: 1146897..1147481 (585 bp)
Type: Others
Protein ID: WP_013284107.1
Location: 1147481..1148479 (999 bp)
Type: Others
Protein ID: WP_013474050.1
Location: 1141818..1141997 (180 bp)
Type: Others
Protein ID: WP_013284098.1
Location: 1143821..1144138 (318 bp)
Type: Antitoxin
Protein ID: WP_013284102.1
Location: 1144135..1144497 (363 bp)
Type: Toxin
Protein ID: WP_013474046.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ML5_RS057051139016..1139651+636WP_013284094.1septum formation initiator family protein-
ML5_RS057101139675..1140232+558WP_013284095.1DUF501 domain-containing protein-
ML5_RS057151140234..1140743+510WP_013284096.1amino-acid N-acetyltransferase-
ML5_RS057201140786..1141715+930WP_013474042.1Ppx/GppA family phosphatase-
ML5_RS057251141818..1141997-180WP_013284098.1hypothetical protein-
ML5_RS057301142098..1142385+288WP_013474043.1hypothetical protein-
ML5_RS057351142450..1142782+333WP_030271259.1PadR family transcriptional regulator-
ML5_RS057401142779..1143738+960WP_013474045.1hypothetical protein-
ML5_RS057451143821..1144138-318WP_013284102.1helix-turn-helix domain-containing proteinAntitoxin
ML5_RS057501144135..1144497-363WP_013474046.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ML5_RS057551144675..1145415+741WP_013474047.1dienelactone hydrolase family protein-
ML5_RS057601145435..1146148+714WP_013474048.1uracil-DNA glycosylase-
ML5_RS057651146169..1146900+732WP_013474049.1DUF4129 domain-containing protein-
ML5_RS057701146897..1147481+585WP_013284107.1hypothetical protein-
ML5_RS057751147481..1148479+999WP_013474050.1MoxR family ATPase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13581.42 Da        Isoelectric Point: 6.0857

>T24999 WP_013474046.1 NC_014815:c1144497-1144135 [Micromonospora sp. L5]
VVAGDWDVYLVDEVRQWLDTLDASTHARVVQAIDLLAEHGPGLGRPLVDTIHGSSMANLKELRPGTVRILFAFDPWRSSI
LLVAGDKSGRWKTWYQEAIPVAEHRYELYLKDRAREEGKA

Download         Length: 363 bp

>T24999 NC_014815:c1144497-1144135 [Micromonospora sp. L5]
GTGGTGGCTGGAGACTGGGACGTCTACCTGGTCGACGAGGTGCGGCAGTGGCTCGACACTCTCGACGCGTCCACCCATGC
GCGAGTGGTGCAGGCGATCGACCTCCTGGCCGAGCACGGACCAGGACTCGGACGACCCCTTGTCGACACCATCCACGGTT
CGTCGATGGCGAACTTGAAGGAGCTCCGGCCGGGCACCGTGCGTATCCTTTTCGCGTTCGACCCGTGGCGCTCGAGCATC
CTCCTGGTCGCCGGCGACAAGTCCGGCCGGTGGAAGACGTGGTATCAGGAGGCCATTCCCGTCGCCGAGCACCGCTACGA
GCTCTACCTCAAGGACCGGGCACGAGAGGAGGGGAAGGCATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11399.80 Da        Isoelectric Point: 6.7267

>AT24999 WP_013284102.1 NC_014815:c1144138-1143821 [Micromonospora sp. L5]
MSDYSRWQDIRADHVARVGGEDAVDAGKQELLAEVIGHRLAEVRRARGLTQQQVADRMGVTKGRVSQIEQGKISGQEVVA
RFAAALGGRLHQAIYFDDGDIAAIA

Download         Length: 318 bp

>AT24999 NC_014815:c1144138-1143821 [Micromonospora sp. L5]
ATGAGCGACTACTCCCGGTGGCAGGACATCCGCGCCGACCACGTCGCCCGGGTCGGCGGGGAAGATGCGGTCGACGCGGG
TAAGCAGGAACTCCTCGCCGAGGTCATCGGTCACCGCCTCGCGGAGGTACGGCGAGCGCGCGGCCTGACCCAGCAGCAGG
TCGCCGACCGGATGGGCGTCACCAAGGGACGGGTCTCCCAGATCGAGCAGGGAAAGATCTCCGGACAGGAAGTGGTGGCC
CGGTTCGCCGCGGCGCTGGGTGGCCGGCTCCACCAGGCGATCTACTTCGACGACGGTGACATCGCCGCCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1C6T5J3

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References