Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2339470..2340032 Replicon chromosome
Accession NZ_CP099914
Organism Escherichia albertii strain 104_2_TS_A

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIY84_RS11290 Protein ID WP_000605679.1
Coordinates 2339470..2339748 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY84_RS11295 Protein ID WP_000781369.1
Coordinates 2339748..2340032 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY84_RS11270 (2335450) 2335450..2335881 - 432 WP_000152289.1 peroxiredoxin OsmC -
NIY84_RS11275 (2336148) 2336148..2336285 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIY84_RS11280 (2336442) 2336442..2338139 + 1698 WP_000433442.1 malate dehydrogenase -
NIY84_RS11285 (2338274) 2338274..2339284 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
NIY84_RS11290 (2339470) 2339470..2339748 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY84_RS11295 (2339748) 2339748..2340032 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIY84_RS11300 (2340037) 2340037..2340513 - 477 WP_059225294.1 NUDIX domain-containing protein -
NIY84_RS11305 (2340643) 2340643..2341101 - 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
NIY84_RS11310 (2341297) 2341297..2341950 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIY84_RS11315 (2341943) 2341943..2342827 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2340643..2341101 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249982 WP_000605679.1 NZ_CP099914:2339470-2339748 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249982 WP_000781369.1 NZ_CP099914:2339748-2340032 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References