Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 649282..650009 Replicon chromosome
Accession NZ_CP099914
Organism Escherichia albertii strain 104_2_TS_A

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag NIY84_RS03195 Protein ID WP_000550189.1
Coordinates 649282..649596 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY84_RS03200 Protein ID WP_256878813.1
Coordinates 649593..650009 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY84_RS03175 (645441) 645441..646427 - 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -
NIY84_RS03180 (646506) 646506..647198 - 693 WP_000942533.1 vancomycin high temperature exclusion protein -
NIY84_RS03185 (647275) 647275..647778 - 504 WP_001295542.1 M48 family metallopeptidase -
NIY84_RS03190 (647863) 647863..648999 + 1137 WP_060877474.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NIY84_RS03195 (649282) 649282..649596 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
NIY84_RS03200 (649593) 649593..650009 + 417 WP_256878813.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NIY84_RS03205 (650099) 650099..652117 - 2019 WP_256878814.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NIY84_RS03210 (652565) 652565..654916 - 2352 WP_000695424.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T249972 WP_000550189.1 NZ_CP099914:649282-649596 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14983.36 Da        Isoelectric Point: 4.3697

>AT249972 WP_256878813.1 NZ_CP099914:649593-650009 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMSGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References