Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 607756..608555 Replicon chromosome
Accession NZ_CP099914
Organism Escherichia albertii strain 104_2_TS_A

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag NIY84_RS02995 Protein ID WP_059227548.1
Coordinates 607756..608220 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NIY84_RS03000 Protein ID WP_001296435.1
Coordinates 608220..608555 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY84_RS02965 (602757) 602757..603191 - 435 WP_149451364.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NIY84_RS02970 (603209) 603209..604087 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIY84_RS02975 (604077) 604077..604856 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIY84_RS02980 (604867) 604867..605340 - 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIY84_RS02985 (605363) 605363..606643 - 1281 WP_256878807.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIY84_RS02990 (606892) 606892..607701 + 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
NIY84_RS02995 (607756) 607756..608220 - 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIY84_RS03000 (608220) 608220..608555 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIY84_RS03005 (608704) 608704..610275 - 1572 WP_256878808.1 galactarate dehydratase -
NIY84_RS03010 (610646) 610646..611980 + 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
NIY84_RS03015 (611996) 611996..612766 + 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T249971 WP_059227548.1 NZ_CP099914:c608220-607756 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT249971 WP_001296435.1 NZ_CP099914:c608555-608220 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References