Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 252716..253416 Replicon chromosome
Accession NZ_CP099914
Organism Escherichia albertii strain 104_2_TS_A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIY84_RS01135 Protein ID WP_256879206.1
Coordinates 253126..253416 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY84_RS01130 Protein ID WP_000806446.1
Coordinates 252716..253054 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY84_RS01105 (247755) 247755..249737 + 1983 WP_059251954.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
NIY84_RS01110 (249786) 249786..250814 + 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
NIY84_RS01115 (250886) 250886..251416 - 531 WP_256879204.1 LuxR C-terminal-related transcriptional regulator -
NIY84_RS01120 (251563) 251563..252129 - 567 WP_059216822.1 outer membrane lipoprotein Slp -
NIY84_RS01125 (252476) 252476..252625 - 150 WP_233991781.1 hypothetical protein -
NIY84_RS01130 (252716) 252716..253054 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
NIY84_RS01135 (253126) 253126..253416 - 291 WP_256879206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY84_RS01140 (253593) 253593..254072 + 480 WP_059215194.1 hypothetical protein -
NIY84_RS01145 (254162) 254162..254335 - 174 WP_000553433.1 hypothetical protein -
NIY84_RS01150 (254363) 254363..254446 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
NIY84_RS01155 (254500) 254500..255852 - 1353 WP_054410173.1 glutathione-disulfide reductase -
NIY84_RS01160 (255924) 255924..256766 - 843 WP_010326142.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11429.03 Da        Isoelectric Point: 8.8483

>T249969 WP_256879206.1 NZ_CP099914:c253416-253126 [Escherichia albertii]
INIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNCYSSIRVNNQYRLIFK
WVNGKAEDLYLDPHKY

Download         Length: 291 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT249969 WP_000806446.1 NZ_CP099914:c253054-252716 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References