Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2427402..2427964 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIY85_RS12050 Protein ID WP_000605679.1
Coordinates 2427402..2427680 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NIY85_RS12055 Protein ID WP_000781370.1
Coordinates 2427680..2427964 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS12030 (2423382) 2423382..2423813 - 432 WP_256876687.1 peroxiredoxin OsmC -
NIY85_RS12035 (2424080) 2424080..2424217 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIY85_RS12040 (2424374) 2424374..2426071 + 1698 WP_000433442.1 malate dehydrogenase -
NIY85_RS12045 (2426206) 2426206..2427216 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
NIY85_RS12050 (2427402) 2427402..2427680 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY85_RS12055 (2427680) 2427680..2427964 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NIY85_RS12060 (2428192) 2428192..2428845 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIY85_RS12065 (2428838) 2428838..2429722 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIY85_RS12070 (2429735) 2429735..2432782 - 3048 WP_077696004.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249956 WP_000605679.1 NZ_CP099912:2427402-2427680 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT249956 WP_000781370.1 NZ_CP099912:2427680-2427964 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References