Detailed information of TA system TA249952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2016861..2017232
• Replicon: chromosome
• Accession: NZ_CP099912
• Organism: Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A891STD1
• Locus tag: NIY85_RS09795
• Protein ID: WP_042853000.1
• Coordinates: 2017038..2017232 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2016861..2017039 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIY85_RS09755 (2012301)	2012301..2012957	-	657	WP_025238866.1	carbon-nitrogen hydrolase family protein YobB	-
NIY85_RS09760 (2013059)	2013059..2013289	-	231	WP_000916758.1	DNA polymerase III subunit theta	-
NIY85_RS09765 (2013428)	2013428..2013805	+	378	WP_256876740.1	CopC domain-containing protein YobA	-
NIY85_RS09770 (2013809)	2013809..2014681	+	873	WP_025238867.1	copper homeostasis membrane protein CopD	-
NIY85_RS09775 (2014694)	2014694..2015035	+	342	WP_000976487.1	DUF2511 domain-containing protein	-
NIY85_RS09780 (2015427)	2015427..2016503	-	1077	WP_256876741.1	phage integrase Arm DNA-binding domain-containing protein	-
NIY85_RS09785 (2016469)	2016469..2016750	-	282	WP_001311878.1	excisionase	-
- (2016861)	2016861..2017039	+	179	NuclAT_0	-	Antitoxin
- (2016861)	2016861..2017039	+	179	NuclAT_0	-	Antitoxin
- (2016861)	2016861..2017039	+	179	NuclAT_0	-	Antitoxin
- (2016861)	2016861..2017039	+	179	NuclAT_0	-	Antitoxin
NIY85_RS09790 (2016857)	2016857..2017045	-	189	WP_001356607.1	DUF1187 family protein	-
NIY85_RS09795 (2017038)	2017038..2017232	-	195	WP_042853000.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
NIY85_RS09800 (2017289)	2017289..2018098	-	810	WP_000166317.1	recombination protein RecT	-
NIY85_RS09805 (2018091)	2018091..2020745	-	2655	WP_112022726.1	exodeoxyribonuclease VIII	-
NIY85_RS09810 (2020845)	2020845..2021120	-	276	WP_001452559.1	hypothetical protein	-
NIY85_RS09815 (2021195)	2021195..2021365	-	171	WP_001359121.1	YdaE family protein	-
NIY85_RS09820 (2021365)	2021365..2021586	-	222	WP_000560227.1	cell division protein FtsZ	-
NIY85_RS09825 (2021998)	2021998..2022150	-	153	WP_000379561.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2015427..2028265	12838
	-	inside	Prophage	-	-	1946108..2079226	133118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7019.87 Da
• Isoelectric Point: 8.6419

>T249952 WP_042853000.1 NZ_CP099912:c2017232-2017038 [Escherichia albertii]
MRYDDVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

Antitoxin

Nucleotide

• Length: 179 bp

>AT249952 NZ_CP099912:2016861-2017039 [Escherichia albertii]
GAGGACAGAAGTTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGACACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAATTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCTTTTT
CAATAGTGGCAGTTATTTT

Structures

Antitoxin