Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 189779..190491 Replicon chromosome
Accession NZ_CP099912
Organism Escherichia albertii strain 105_1_LWG_A

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag NIY85_RS00875 Protein ID WP_000162413.1
Coordinates 189779..190081 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY85_RS00880 Protein ID WP_000806446.1
Coordinates 190153..190491 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY85_RS00850 (186442) 186442..187284 + 843 WP_025238143.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
NIY85_RS00855 (187356) 187356..188708 + 1353 WP_256876822.1 glutathione-disulfide reductase -
NIY85_RS00860 (188762) 188762..188845 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
NIY85_RS00865 (188873) 188873..189046 + 174 WP_000553433.1 hypothetical protein -
NIY85_RS00870 (189136) 189136..189615 - 480 WP_025238141.1 hypothetical protein -
NIY85_RS00875 (189779) 189779..190081 + 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY85_RS00880 (190153) 190153..190491 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
NIY85_RS00885 (190548) 190548..190715 + 168 WP_232529606.1 hypothetical protein -
NIY85_RS00890 (191077) 191077..191643 + 567 WP_001044206.1 outer membrane lipoprotein Slp -
NIY85_RS00895 (191790) 191790..192320 + 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
NIY85_RS00900 (192392) 192392..193420 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
NIY85_RS00905 (193469) 193469..195450 - 1982 Protein_181 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T249944 WP_000162413.1 NZ_CP099912:189779-190081 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT249944 WP_000806446.1 NZ_CP099912:190153-190491 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References