Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3714653..3715303 Replicon chromosome
Accession NZ_CP099910
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIY87_RS18205 Protein ID WP_059224977.1
Coordinates 3714962..3715303 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIY87_RS18200 Protein ID WP_025237546.1
Coordinates 3714653..3714952 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS18170 (3709783) 3709783..3710094 - 312 WP_059224980.1 hypothetical protein -
NIY87_RS18175 (3710099) 3710099..3710491 - 393 WP_000273381.1 flagellar export chaperone FliS -
NIY87_RS18180 (3710514) 3710514..3711830 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIY87_RS18185 (3711897) 3711897..3712232 - 336 WP_256876143.1 hypothetical protein -
NIY87_RS18190 (3712343) 3712343..3713257 - 915 WP_000949079.1 lateral flagellin LafA -
NIY87_RS18195 (3713744) 3713744..3714595 + 852 WP_233991701.1 winged helix-turn-helix domain-containing protein -
NIY87_RS18200 (3714653) 3714653..3714952 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIY87_RS18205 (3714962) 3714962..3715303 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY87_RS18210 (3715379) 3715379..3716356 - 978 WP_059224976.1 hypothetical protein -
NIY87_RS18215 (3716373) 3716373..3717302 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIY87_RS18220 (3717317) 3717317..3718693 - 1377 WP_233991702.1 flagellar hook-associated protein FlgK -
NIY87_RS18225 (3719251) 3719251..3719550 - 300 WP_059224974.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249931 WP_059224977.1 NZ_CP099910:c3715303-3714962 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249931 WP_025237546.1 NZ_CP099910:c3714952-3714653 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References