Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2516606..2517168 Replicon chromosome
Accession NZ_CP099910
Organism Escherichia albertii strain 110_1_TBG_A

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag NIY87_RS12455 Protein ID WP_000605676.1
Coordinates 2516606..2516884 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY87_RS12460 Protein ID WP_000781369.1
Coordinates 2516884..2517168 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY87_RS12435 (2512596) 2512596..2513027 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIY87_RS12440 (2513285) 2513285..2513422 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIY87_RS12445 (2513579) 2513579..2515276 + 1698 WP_059225292.1 malate dehydrogenase -
NIY87_RS12450 (2515410) 2515410..2516420 + 1011 WP_059225293.1 alcohol dehydrogenase AdhP -
NIY87_RS12455 (2516606) 2516606..2516884 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY87_RS12460 (2516884) 2516884..2517168 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIY87_RS12465 (2517173) 2517173..2517649 - 477 WP_059225294.1 NUDIX domain-containing protein -
NIY87_RS12470 (2517722) 2517722..2518375 - 654 WP_256876185.1 formate dehydrogenase-N subunit gamma -
NIY87_RS12475 (2518368) 2518368..2519252 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T249927 WP_000605676.1 NZ_CP099910:2516606-2516884 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249927 WP_000781369.1 NZ_CP099910:2516884-2517168 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References