Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3717225..3717875 Replicon chromosome
Accession NZ_CP099907
Organism Escherichia albertii strain 112_1_EW_A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIY89_RS18235 Protein ID WP_059224977.1
Coordinates 3717534..3717875 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIY89_RS18230 Protein ID WP_025237546.1
Coordinates 3717225..3717524 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY89_RS18200 (3712355) 3712355..3712666 - 312 WP_059224980.1 hypothetical protein -
NIY89_RS18205 (3712671) 3712671..3713063 - 393 WP_000273381.1 flagellar export chaperone FliS -
NIY89_RS18210 (3713086) 3713086..3714402 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIY89_RS18215 (3714469) 3714469..3714804 - 336 WP_256876143.1 hypothetical protein -
NIY89_RS18220 (3714915) 3714915..3715829 - 915 WP_000949079.1 lateral flagellin LafA -
NIY89_RS18225 (3716316) 3716316..3717167 + 852 WP_233991701.1 winged helix-turn-helix domain-containing protein -
NIY89_RS18230 (3717225) 3717225..3717524 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIY89_RS18235 (3717534) 3717534..3717875 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY89_RS18240 (3717951) 3717951..3718928 - 978 WP_059224976.1 hypothetical protein -
NIY89_RS18245 (3718945) 3718945..3719874 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIY89_RS18250 (3719889) 3719889..3721265 - 1377 WP_233991702.1 flagellar hook-associated protein FlgK -
NIY89_RS18255 (3721823) 3721823..3722122 - 300 WP_059224974.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249904 WP_059224977.1 NZ_CP099907:c3717875-3717534 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249904 WP_025237546.1 NZ_CP099907:c3717524-3717225 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References