Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2849756..2850456 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIY90_RS13980 Protein ID WP_256879206.1
Coordinates 2849756..2850046 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY90_RS13985 Protein ID WP_000806446.1
Coordinates 2850118..2850456 (+) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS13955 (2846406) 2846406..2847248 + 843 WP_010326142.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -
NIY90_RS13960 (2847320) 2847320..2848672 + 1353 WP_054410173.1 glutathione-disulfide reductase -
NIY90_RS13965 (2848726) 2848726..2848809 - 84 WP_001295215.1 damage-inducible type I toxin DinQ -
NIY90_RS13970 (2848837) 2848837..2849010 + 174 WP_000553433.1 hypothetical protein -
NIY90_RS13975 (2849100) 2849100..2849579 - 480 WP_059215194.1 hypothetical protein -
NIY90_RS13980 (2849756) 2849756..2850046 + 291 WP_256879206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY90_RS13985 (2850118) 2850118..2850456 + 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
NIY90_RS13990 (2850547) 2850547..2850696 + 150 WP_233991781.1 hypothetical protein -
NIY90_RS13995 (2851043) 2851043..2851609 + 567 WP_059216822.1 outer membrane lipoprotein Slp -
NIY90_RS14000 (2851756) 2851756..2852286 + 531 WP_256879204.1 LuxR C-terminal-related transcriptional regulator -
NIY90_RS14005 (2852358) 2852358..2853386 - 1029 WP_001110408.1 hematinate-forming heme oxygenase ChuS -
NIY90_RS14010 (2853435) 2853435..2855417 - 1983 WP_059251954.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11429.03 Da        Isoelectric Point: 8.8483

>T249880 WP_256879206.1 NZ_CP099906:2849756-2850046 [Escherichia albertii]
INIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNCYSSIRVNNQYRLIFK
WVNGKAEDLYLDPHKY

Download         Length: 291 bp

>T249880 NZ_CP099906:2849756-2850046 [Escherichia albertii]
ATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACACAAAAAGATACCTTCTGA
TATTCATATTACATTGTTGCGGAAGCTGGATATTATCAATGCCGCAACGACCTGGAAGGACTTGAGATCACCACCAGGTA
ATCGGTATGAGGAATTGTCAGGGAAGCTAAACTGCTATTCATCAATAAGGGTGAATAATCAATATAGGTTAATTTTTAAG
TGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT249880 WP_000806446.1 NZ_CP099906:2850118-2850456 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp

>AT249880 NZ_CP099906:2850118-2850456 [Escherichia albertii]
ATGAAACAGGCAACCAGAAAACCGACGACTGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTTAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGCAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGACCTGTGG
GAAGTTGAAAATGATATGCGCGTTCAGGAAGAGTTAAGCCGTATCACTACTGCTGAAGAATTTATTTCTCAGCGGAATCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References