Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2494838..2495637 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag NIY90_RS12115 Protein ID WP_059227548.1
Coordinates 2495173..2495637 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NIY90_RS12110 Protein ID WP_001296435.1
Coordinates 2494838..2495173 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS12095 (2490627) 2490627..2491397 - 771 WP_025238278.1 2-dehydro-3-deoxyglucarate aldolase -
NIY90_RS12100 (2491413) 2491413..2492747 - 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
NIY90_RS12105 (2493118) 2493118..2494689 + 1572 WP_256878808.1 galactarate dehydratase -
NIY90_RS12110 (2494838) 2494838..2495173 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIY90_RS12115 (2495173) 2495173..2495637 + 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIY90_RS12120 (2495692) 2495692..2496501 - 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
NIY90_RS12125 (2496750) 2496750..2498030 + 1281 WP_256878807.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIY90_RS12130 (2498053) 2498053..2498526 + 474 WP_002461030.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIY90_RS12135 (2498537) 2498537..2499316 + 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIY90_RS12140 (2499306) 2499306..2500184 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIY90_RS12145 (2500202) 2500202..2500636 + 435 WP_149451364.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T249878 WP_059227548.1 NZ_CP099906:2495173-2495637 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT249878 WP_001296435.1 NZ_CP099906:2494838-2495173 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References