Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2453384..2454111 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag NIY90_RS11915 Protein ID WP_000550189.1
Coordinates 2453797..2454111 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY90_RS11910 Protein ID WP_256878813.1
Coordinates 2453384..2453800 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS11900 (2448477) 2448477..2450828 + 2352 WP_000695424.1 alpha-glucosidase -
NIY90_RS11905 (2451276) 2451276..2453294 + 2019 WP_256878814.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NIY90_RS11910 (2453384) 2453384..2453800 - 417 WP_256878813.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NIY90_RS11915 (2453797) 2453797..2454111 - 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
NIY90_RS11920 (2454394) 2454394..2455530 - 1137 WP_060877474.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NIY90_RS11925 (2455615) 2455615..2456118 + 504 WP_001295542.1 M48 family metallopeptidase -
NIY90_RS11930 (2456195) 2456195..2456887 + 693 WP_000942533.1 vancomycin high temperature exclusion protein -
NIY90_RS11935 (2456966) 2456966..2457952 + 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T249877 WP_000550189.1 NZ_CP099906:c2454111-2453797 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14983.36 Da        Isoelectric Point: 4.3697

>AT249877 WP_256878813.1 NZ_CP099906:c2453800-2453384 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMSGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References