Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2011860..2012587 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag NIY90_RS09905 Protein ID WP_000547563.1
Coordinates 2012276..2012587 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY90_RS09900 Protein ID WP_000126297.1
Coordinates 2011860..2012279 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS09885 (2007979) 2007979..2010231 - 2253 WP_256878885.1 carbamoyltransferase HypF -
NIY90_RS09890 (2010384) 2010384..2010911 - 528 WP_001078780.1 electron transport protein HydN -
NIY90_RS09895 (2011340) 2011340..2011768 + 429 WP_000536064.1 hypothetical protein -
NIY90_RS09900 (2011860) 2011860..2012279 - 420 WP_000126297.1 helix-turn-helix domain-containing protein Antitoxin
NIY90_RS09905 (2012276) 2012276..2012587 - 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
NIY90_RS09910 (2012749) 2012749..2013504 - 756 WP_125060797.1 hypothetical protein -
NIY90_RS09915 (2013547) 2013547..2014017 - 471 WP_059219259.1 hydrogenase maturation peptidase HycI -
NIY90_RS09920 (2014010) 2014010..2014420 - 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
NIY90_RS09925 (2014417) 2014417..2015184 - 768 WP_059214453.1 formate hydrogenlyase subunit HycG -
NIY90_RS09930 (2015184) 2015184..2015726 - 543 WP_000493797.1 formate hydrogenlyase subunit HycF -
NIY90_RS09935 (2015736) 2015736..2017445 - 1710 WP_256921794.1 formate hydrogenlyase subunit HycE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T249874 WP_000547563.1 NZ_CP099906:c2012587-2012276 [Escherichia albertii]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15446.45 Da        Isoelectric Point: 4.4596

>AT249874 WP_000126297.1 NZ_CP099906:c2012279-2011860 [Escherichia albertii]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References