Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 732031..732593 Replicon chromosome
Accession NZ_CP099906
Organism Escherichia albertii strain 121_1_EW_A

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIY90_RS03600 Protein ID WP_000605679.1
Coordinates 732315..732593 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY90_RS03595 Protein ID WP_000781369.1
Coordinates 732031..732315 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY90_RS03575 (729236) 729236..730120 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIY90_RS03580 (730113) 730113..730766 + 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIY90_RS03585 (730962) 730962..731420 + 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
NIY90_RS03590 (731550) 731550..732026 + 477 WP_059225294.1 NUDIX domain-containing protein -
NIY90_RS03595 (732031) 732031..732315 - 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIY90_RS03600 (732315) 732315..732593 - 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY90_RS03605 (732779) 732779..733789 - 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
NIY90_RS03610 (733924) 733924..735621 - 1698 WP_000433442.1 malate dehydrogenase -
NIY90_RS03615 (735778) 735778..735915 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIY90_RS03620 (736182) 736182..736613 + 432 WP_000152289.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 730962..731420 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249867 WP_000605679.1 NZ_CP099906:c732593-732315 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249867 WP_000781369.1 NZ_CP099906:c732315-732031 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References