Detailed information of TA system TA249865

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 85564..85990
• Replicon: plasmid plas2
• Accession: NZ_CP099905
• Organism: Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: NIY95_RS24995
• Protein ID: WP_001372321.1
• Coordinates: 85865..85990 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	85564..85788 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIY95_RS24950 (80790)	80790..81017	+	228	WP_071594011.1	hypothetical protein	-
NIY95_RS24955 (81258)	81258..81464	+	207	WP_000547971.1	hypothetical protein	-
NIY95_RS24960 (81490)	81490..82029	+	540	WP_000290812.1	single-stranded DNA-binding protein	-
NIY95_RS24965 (82091)	82091..82324	+	234	WP_000006030.1	DUF905 family protein	-
NIY95_RS24970 (82389)	82389..84347	+	1959	WP_000117210.1	ParB/RepB/Spo0J family partition protein	-
NIY95_RS24975 (84402)	84402..84836	+	435	WP_000845873.1	conjugation system SOS inhibitor PsiB	-
NIY95_RS24980 (84833)	84833..85595	+	763	Protein_95	plasmid SOS inhibition protein A	-
NIY95_RS24985 (85564)	85564..85752	-	189	WP_001299721.1	hypothetical protein	-
- (85564)	85564..85788	+	225	NuclAT_0	-	Antitoxin
- (85564)	85564..85788	+	225	NuclAT_0	-	Antitoxin
- (85564)	85564..85788	+	225	NuclAT_0	-	Antitoxin
- (85564)	85564..85788	+	225	NuclAT_0	-	Antitoxin
NIY95_RS24990 (85774)	85774..85923	+	150	Protein_97	plasmid maintenance protein Mok	-
NIY95_RS24995 (85865)	85865..85990	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
NIY95_RS25000 (86210)	86210..86440	+	231	WP_256876178.1	hypothetical protein	-
NIY95_RS25005 (86438)	86438..86611	-	174	Protein_100	hypothetical protein	-
NIY95_RS25010 (86681)	86681..86887	+	207	WP_000547971.1	hypothetical protein	-
NIY95_RS25015 (86912)	86912..87199	+	288	WP_000107535.1	hypothetical protein	-
NIY95_RS25020 (87319)	87319..88140	+	822	WP_001234469.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	espL2	1..89077	89077

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T249865 WP_001372321.1 NZ_CP099905:85865-85990 [Escherichia albertii]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT249865 NZ_CP099905:85564-85788 [Escherichia albertii]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin