Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3708099..3708749 Replicon chromosome
Accession NZ_CP099903
Organism Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIY95_RS18115 Protein ID WP_059224977.1
Coordinates 3708408..3708749 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIY95_RS18110 Protein ID WP_025237546.1
Coordinates 3708099..3708398 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY95_RS18080 (3703229) 3703229..3703540 - 312 WP_059224980.1 hypothetical protein -
NIY95_RS18085 (3703545) 3703545..3703937 - 393 WP_000273381.1 flagellar export chaperone FliS -
NIY95_RS18090 (3703960) 3703960..3705276 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIY95_RS18095 (3705343) 3705343..3705678 - 336 WP_256876143.1 hypothetical protein -
NIY95_RS18100 (3705789) 3705789..3706703 - 915 WP_000949079.1 lateral flagellin LafA -
NIY95_RS18105 (3707190) 3707190..3708041 + 852 WP_233991701.1 winged helix-turn-helix domain-containing protein -
NIY95_RS18110 (3708099) 3708099..3708398 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIY95_RS18115 (3708408) 3708408..3708749 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY95_RS18120 (3708825) 3708825..3709802 - 978 Protein_3536 flagellar hook-associated protein -
NIY95_RS18125 (3709819) 3709819..3710748 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIY95_RS18130 (3710763) 3710763..3712139 - 1377 WP_233991702.1 flagellar hook-associated protein FlgK -
NIY95_RS18135 (3712697) 3712697..3712996 - 300 WP_059224974.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249855 WP_059224977.1 NZ_CP099903:c3708749-3708408 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249855 WP_025237546.1 NZ_CP099903:c3708398-3708099 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References