Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2476188..2476750 Replicon chromosome
Accession NZ_CP099903
Organism Escherichia albertii strain 133_1_GWG_A

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag NIY95_RS12145 Protein ID WP_000605676.1
Coordinates 2476188..2476466 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIY95_RS12150 Protein ID WP_000781369.1
Coordinates 2476466..2476750 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIY95_RS12125 (2472178) 2472178..2472609 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIY95_RS12130 (2472867) 2472867..2473004 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIY95_RS12135 (2473161) 2473161..2474858 + 1698 WP_059225292.1 malate dehydrogenase -
NIY95_RS12140 (2474992) 2474992..2476002 + 1011 WP_059225293.1 alcohol dehydrogenase AdhP -
NIY95_RS12145 (2476188) 2476188..2476466 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIY95_RS12150 (2476466) 2476466..2476750 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIY95_RS12155 (2476755) 2476755..2477231 - 477 WP_059225294.1 NUDIX domain-containing protein -
NIY95_RS12160 (2477304) 2477304..2477957 - 654 WP_256876185.1 formate dehydrogenase-N subunit gamma -
NIY95_RS12165 (2477950) 2477950..2478834 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T249851 WP_000605676.1 NZ_CP099903:2476188-2476466 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249851 WP_000781369.1 NZ_CP099903:2476466-2476750 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References