Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 594425..595224 Replicon chromosome
Accession NZ_CP099898
Organism Escherichia albertii strain 147_1_TBG_A

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag NIZ13_RS02925 Protein ID WP_059235443.1
Coordinates 594425..594889 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NIZ13_RS02930 Protein ID WP_001296435.1
Coordinates 594889..595224 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ13_RS02895 (589426) 589426..589860 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NIZ13_RS02900 (589878) 589878..590756 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIZ13_RS02905 (590746) 590746..591525 - 780 WP_105175636.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIZ13_RS02910 (591536) 591536..592009 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIZ13_RS02915 (592032) 592032..593312 - 1281 WP_059235447.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIZ13_RS02920 (593561) 593561..594370 + 810 WP_059235445.1 aga operon transcriptional regulator AgaR -
NIZ13_RS02925 (594425) 594425..594889 - 465 WP_059235443.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIZ13_RS02930 (594889) 594889..595224 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIZ13_RS02935 (595373) 595373..596944 - 1572 WP_059235441.1 galactarate dehydratase -
NIZ13_RS02940 (597315) 597315..598649 + 1335 WP_059241781.1 galactarate/glucarate/glycerate transporter GarP -
NIZ13_RS02945 (598665) 598665..599435 + 771 WP_059235438.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17825.22 Da        Isoelectric Point: 9.6804

>T249818 WP_059235443.1 NZ_CP099898:c594889-594425 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSSAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT249818 WP_001296435.1 NZ_CP099898:c595224-594889 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References