Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 593756..594555 Replicon chromosome
Accession NZ_CP099895
Organism Escherichia albertii strain 153_2_TBG_A

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag NIZ14_RS02925 Protein ID WP_059235443.1
Coordinates 593756..594220 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NIZ14_RS02930 Protein ID WP_001296435.1
Coordinates 594220..594555 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ14_RS02895 (588757) 588757..589191 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NIZ14_RS02900 (589209) 589209..590087 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIZ14_RS02905 (590077) 590077..590856 - 780 WP_105175636.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIZ14_RS02910 (590867) 590867..591340 - 474 WP_059218168.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIZ14_RS02915 (591363) 591363..592643 - 1281 WP_059235447.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIZ14_RS02920 (592892) 592892..593701 + 810 WP_059235445.1 aga operon transcriptional regulator AgaR -
NIZ14_RS02925 (593756) 593756..594220 - 465 WP_059235443.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIZ14_RS02930 (594220) 594220..594555 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIZ14_RS02935 (594704) 594704..596275 - 1572 WP_059235441.1 galactarate dehydratase -
NIZ14_RS02940 (596646) 596646..597980 + 1335 WP_059241781.1 galactarate/glucarate/glycerate transporter GarP -
NIZ14_RS02945 (597996) 597996..598766 + 771 WP_059235438.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17825.22 Da        Isoelectric Point: 9.6804

>T249792 WP_059235443.1 NZ_CP099895:c594220-593756 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSSAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT249792 WP_001296435.1 NZ_CP099895:c594555-594220 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References