Detailed information of TA system TA024978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2181455..2182161
• Replicon: chromosome
• Accession: NC_014722
• Organism: Burkholderia rhizoxinica HKI 454

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: E5AT95
• Locus tag: RBRH_RS09475
• Protein ID: WP_013435998.1
• Coordinates: 2181455..2181757 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: RBRH_RS09480
• Protein ID: WP_041753754.1
• Coordinates: 2181760..2182161 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RBRH_RS19935	2176480..2176686	+	207	WP_013435991.1	hypothetical protein	-
RBRH_RS09455	2177233..2178609	+	1377	WP_013435992.1	hypothetical protein	-
RBRH_RS09460	2178770..2179666	+	897	WP_013435993.1	hypothetical protein	-
RBRH_RS09465	2179639..2179884	+	246	WP_157864419.1	hypothetical protein	-
RBRH_RS17370	2180107..2181360	-	1254	Protein_1893	error-prone DNA polymerase	-
RBRH_RS09475	2181455..2181757	+	303	WP_013435998.1	type II toxin-antitoxin system MqsR family toxin	Toxin
RBRH_RS09480	2181760..2182161	+	402	WP_041753754.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
RBRH_RS09485	2182465..2183838	+	1374	WP_013436000.1	hypothetical protein	-
RBRH_RS09495	2184475..2185353	-	879	Protein_1897	spermidine synthase	-
RBRH_RS09500	2185630..2186106	-	477	WP_013436002.1	DNA-deoxyinosine glycosylase	-
RBRH_RS09505	2186114..2186695	-	582	WP_013436003.1	chorismate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11013.81 Da
• Isoelectric Point: 7.9030

>T24978 WP_013435998.1 NC_014722:2181455-2181757 [Mycetohabitans rhizoxinica HKI 454]
MEKGTPHCKLPVVKDLVRVGQVRATASAYSGARELGINDLAGMCAVVLALTPADFYKSMTTHANHRIWQDVYHARTAIGD
QVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T24978 NC_014722:2181455-2181757 [Mycetohabitans rhizoxinica HKI 454]
ATGGAGAAAGGTACCCCGCACTGTAAACTGCCAGTCGTCAAAGATTTGGTCAGGGTCGGACAAGTCCGGGCCACAGCTAG
CGCCTACAGTGGAGCGCGTGAACTTGGCATCAATGATCTGGCCGGGATGTGTGCCGTTGTTTTGGCGCTCACTCCTGCCG
ACTTCTACAAGAGCATGACGACCCATGCCAATCATCGTATTTGGCAGGACGTGTATCACGCCAGGACAGCAATTGGCGAT
CAGGTGTACCTGAAGCTGACCGTCATTGATGACGTGCTGATCGTTTCTTTCAAGGAGCTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14729.87 Da
• Isoelectric Point: 7.6370

>AT24978 WP_041753754.1 NC_014722:2181760-2182161 [Mycetohabitans rhizoxinica HKI 454]
MKCPCCGAAELIHDTRDVPYTYKGETTSIPAVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNAAYVDPGYISKVRKR
LGLDQRQAAELFGGGVNAFSRYENGKTKPPLALVKLFKLLDRHPDLLNEVKTV

Nucleotide

• Length: 402 bp

>AT24978 NC_014722:2181760-2182161 [Mycetohabitans rhizoxinica HKI 454]
ATGAAATGCCCATGCTGCGGCGCGGCGGAACTGATCCACGATACCCGCGATGTGCCCTACACTTACAAAGGTGAAACCAC
CTCCATTCCAGCGGTAACAGGCGACTTTTGCCCTGCCTGCGGTGAAGTCGTCTTGGACCGTGAACACGGCGACCGCTATA
GCGAACTGGTGGGCTTGTTCCAGCGTCAAGTCAATGCCGCCTATGTTGATCCCGGCTATATCTCCAAAGTGCGCAAGAGG
CTCGGCCTTGACCAGCGGCAGGCTGCCGAACTTTTCGGCGGTGGCGTCAATGCTTTCTCGCGCTACGAGAATGGCAAGAC
TAAACCGCCGCTGGCCTTGGTCAAGCTGTTCAAGTTGTTGGATCGTCACCCAGACCTGCTTAACGAGGTCAAAACCGTCT
GA

Structures

Toxin

• AlphaFold DB: E5AT95