Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HTH_XRE
Location 2091312..2092024 Replicon chromosome
Accession NZ_CP099890
Organism Escherichia albertii strain 205_2_TBG_B

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8WCQ7
Locus tag NIZ17_RS10375 Protein ID WP_000162413.1
Coordinates 2091722..2092024 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ17_RS10370 Protein ID WP_000806446.1
Coordinates 2091312..2091650 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ17_RS10345 (2086363) 2086363..2088345 + 1983 WP_124866558.1 TonB-dependent heme/hemoglobin receptor ChuA/ShuA -
NIZ17_RS10350 (2088394) 2088394..2089422 + 1029 WP_103054025.1 hematinate-forming heme oxygenase ChuS -
NIZ17_RS10355 (2089494) 2089494..2090024 - 531 WP_000480294.1 LuxR C-terminal-related transcriptional regulator -
NIZ17_RS10360 (2090171) 2090171..2090737 - 567 WP_001044206.1 outer membrane lipoprotein Slp -
NIZ17_RS10365 (2091084) 2091084..2091221 - 138 WP_199768253.1 hypothetical protein -
NIZ17_RS10370 (2091312) 2091312..2091650 - 339 WP_000806446.1 HigA family addiction module antitoxin Antitoxin
NIZ17_RS10375 (2091722) 2091722..2092024 - 303 WP_000162413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ17_RS10380 (2092188) 2092188..2092667 + 480 WP_256880683.1 hypothetical protein -
NIZ17_RS10385 (2092757) 2092757..2092930 - 174 WP_000553433.1 hypothetical protein -
NIZ17_RS10390 (2092958) 2092958..2093041 + 84 WP_001295215.1 damage-inducible type I toxin DinQ -
NIZ17_RS10395 (2093095) 2093095..2094447 - 1353 WP_054410173.1 glutathione-disulfide reductase -
NIZ17_RS10400 (2094519) 2094519..2095361 - 843 WP_000954227.1 23S rRNA (adenine(2030)-N(6))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-100)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11871.59 Da        Isoelectric Point: 9.8664

>T249754 WP_000162413.1 NZ_CP099890:c2092024-2091722 [Escherichia albertii]
MTKKINIKDFRDAWLDDFFEFSTPHKKIPSDIHITLLRKLDIINAATTWKDLRSPPGNRYEELSGKLNGYSSIRVNNQYR
LIFKWVNGKAEDLYLDPHKY

Download         Length: 303 bp

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 13037.92 Da        Isoelectric Point: 5.2075

>AT249754 WP_000806446.1 NZ_CP099890:c2091650-2091312 [Escherichia albertii]
MKQATRKPTTVGDILLYEYLEPLELKINELAEILHVHRNTVSALVNNNRKLTMDMAYRLAKAFDTSVDFWINLQTAVDLW
EVENDMRVQEELSRITTAEEFISQRNLNKKAA

Download         Length: 339 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8WCQ7

Antitoxin

Source ID Structure

References