Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 730344..730994 Replicon chromosome
Accession NZ_CP099890
Organism Escherichia albertii strain 205_2_TBG_B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIZ17_RS03825 Protein ID WP_059224977.1
Coordinates 730653..730994 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIZ17_RS03820 Protein ID WP_025237546.1
Coordinates 730344..730643 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ17_RS03795 (725681) 725681..725992 - 312 WP_000410252.1 hypothetical protein -
NIZ17_RS03800 (725997) 725997..726386 - 390 WP_256880433.1 flagellar export chaperone FliS -
NIZ17_RS03805 (726409) 726409..727725 - 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIZ17_RS03810 (728034) 728034..728948 - 915 WP_000949079.1 lateral flagellin LafA -
NIZ17_RS03815 (729435) 729435..730286 + 852 WP_000022899.1 winged helix-turn-helix domain-containing protein -
NIZ17_RS03820 (730344) 730344..730643 - 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIZ17_RS03825 (730653) 730653..730994 - 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ17_RS03830 (731070) 731070..732047 - 978 Protein_743 flagellar hook-associated protein -
NIZ17_RS03835 (732064) 732064..732993 - 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIZ17_RS03840 (733008) 733008..734384 - 1377 WP_025237549.1 flagellar hook-associated protein FlgK -
NIZ17_RS03845 (735060) 735060..735359 - 300 WP_059254376.1 rod-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249748 WP_059224977.1 NZ_CP099890:c730994-730653 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249748 WP_025237546.1 NZ_CP099890:c730643-730344 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References