Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 635397..636124 Replicon chromosome
Accession NZ_CP099887
Organism Escherichia albertii strain 208_2_GWG_B

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag NIZ18_RS03130 Protein ID WP_000550189.1
Coordinates 635397..635711 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ18_RS03135 Protein ID WP_000560272.1
Coordinates 635708..636124 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ18_RS03110 (631556) 631556..632542 - 987 WP_000617693.1 Gfo/Idh/MocA family oxidoreductase -
NIZ18_RS03115 (632621) 632621..633313 - 693 WP_059215025.1 vancomycin high temperature exclusion protein -
NIZ18_RS03120 (633390) 633390..633893 - 504 WP_059215024.1 M48 family metallopeptidase -
NIZ18_RS03125 (633978) 633978..635114 + 1137 WP_059241776.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
NIZ18_RS03130 (635397) 635397..635711 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
NIZ18_RS03135 (635708) 635708..636124 + 417 WP_000560272.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
NIZ18_RS03140 (636214) 636214..638232 - 2019 WP_059216457.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
NIZ18_RS03145 (638457) 638457..640808 - 2352 WP_059235423.1 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T249726 WP_000550189.1 NZ_CP099887:635397-635711 [Escherichia albertii]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14993.40 Da        Isoelectric Point: 4.3697

>AT249726 WP_000560272.1 NZ_CP099887:635708-636124 [Escherichia albertii]
MIAIADILQAGEKLTDVAPFLAGIQSEEQYAQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMVQAMPGG
VAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGKRKLTLEHAKKLAARFGISPALFID

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References