Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4013082..4013644 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIZ19_RS19640 Protein ID WP_000605679.1
Coordinates 4013082..4013360 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag NIZ19_RS19645 Protein ID WP_000781370.1
Coordinates 4013360..4013644 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS19620 (4009071) 4009071..4009502 - 432 WP_000152289.1 peroxiredoxin OsmC -
NIZ19_RS19625 (4009760) 4009760..4009897 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ19_RS19630 (4010054) 4010054..4011751 + 1698 WP_059259313.1 malate dehydrogenase -
NIZ19_RS19635 (4011886) 4011886..4012896 + 1011 WP_000642385.1 alcohol dehydrogenase AdhP -
NIZ19_RS19640 (4013082) 4013082..4013360 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ19_RS19645 (4013360) 4013360..4013644 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
NIZ19_RS19650 (4013872) 4013872..4014525 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIZ19_RS19655 (4014518) 4014518..4015402 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIZ19_RS19660 (4015415) 4015415..4018282 - 2868 Protein_3817 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249710 WP_000605679.1 NZ_CP099886:4013082-4013360 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT249710 WP_000781370.1 NZ_CP099886:4013360-4013644 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References