Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 1496326..1497125 Replicon chromosome
Accession NZ_CP099886
Organism Escherichia albertii strain 222_1_EW_B

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9C2I0
Locus tag NIZ19_RS07450 Protein ID WP_059227548.1
Coordinates 1496326..1496790 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag NIZ19_RS07455 Protein ID WP_001296435.1
Coordinates 1496790..1497125 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ19_RS07420 (1491327) 1491327..1491761 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
NIZ19_RS07425 (1491779) 1491779..1492657 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
NIZ19_RS07430 (1492647) 1492647..1493426 - 780 WP_000406226.1 PTS N-acetylgalactosamine transporter subunit IIC -
NIZ19_RS07435 (1493437) 1493437..1493910 - 474 WP_256877556.1 PTS N-acetylgalactosamine transporter subunit IIB -
NIZ19_RS07440 (1493933) 1493933..1495213 - 1281 WP_059227551.1 tagatose-bisphosphate aldolase subunit KbaZ -
NIZ19_RS07445 (1495462) 1495462..1496271 + 810 WP_000072169.1 aga operon transcriptional regulator AgaR -
NIZ19_RS07450 (1496326) 1496326..1496790 - 465 WP_059227548.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
NIZ19_RS07455 (1496790) 1496790..1497125 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
NIZ19_RS07460 (1497274) 1497274..1498845 - 1572 WP_059256163.1 galactarate dehydratase -
NIZ19_RS07465 (1499215) 1499215..1500549 + 1335 WP_025238277.1 galactarate/glucarate/glycerate transporter GarP -
NIZ19_RS07470 (1500565) 1500565..1501335 + 771 WP_001058056.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17819.26 Da        Isoelectric Point: 9.7301

>T249693 WP_059227548.1 NZ_CP099886:c1496790-1496326 [Escherichia albertii]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRFRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTQETEEKH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT249693 WP_001296435.1 NZ_CP099886:c1497125-1496790 [Escherichia albertii]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References