Detailed information of TA system TA249685

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4167891..4168148
• Replicon: chromosome
• Accession: NZ_CP099883
• Organism: Escherichia albertii strain 231_1_NP_B

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: V0YDF1
• Locus tag: NIZ20_RS20315
• Protein ID: WP_001135738.1
• Coordinates: 4167891..4168043 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	4168094..4168148 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIZ20_RS20285	4163995..4164654	+	660	WP_256876081.1	OmpA family lipoprotein	-
NIZ20_RS20290	4164758..4165732	+	975	WP_000804993.1	glyoxylate/hydroxypyruvate reductase GhrB	-
NIZ20_RS20295	4165785..4166495	-	711	WP_002460072.1	DUF3053 domain-containing protein	-
NIZ20_RS20300	4166918..4167208	+	291	WP_059225708.1	HTH-type transcriptional regulator	-
NIZ20_RS20305	4167491..4167703	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
NIZ20_RS20310	4167843..4167914	+	72	WP_212734940.1	hypothetical protein	-
NIZ20_RS20315	4167891..4168043	-	153	WP_001135738.1	type I toxin-antitoxin system toxin HokA	Toxin
-	4168094..4168148	+	55	-	-	Antitoxin
NIZ20_RS20320	4168366..4170435	-	2070	WP_059221279.1	glycine--tRNA ligase subunit beta	-
NIZ20_RS20325	4170445..4171356	-	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
NIZ20_RS20330	4171452..4171751	-	300	WP_256876080.1	YsaB family lipoprotein	-
NIZ20_RS20335	4171924..4172919	+	996	WP_059259085.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5912.14 Da
• Isoelectric Point: 7.7173

>T249685 WP_001135738.1 NZ_CP099883:c4168043-4167891 [Escherichia albertii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQGSYELAAFLACNLKE

Nucleotide

• Length: 153 bp

Antitoxin

Nucleotide

• Length: 55 bp

>AT249685 NZ_CP099883:4168094-4168148 [Escherichia albertii]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A7U9LX93

Antitoxin