Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3433296..3433887 Replicon chromosome
Accession NC_014664
Organism Rhodomicrobium vannielii ATCC 17100

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag RVAN_RS15830 Protein ID WP_013420717.1
Coordinates 3433603..3433887 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RVAN_RS15825 Protein ID WP_013420716.1
Coordinates 3433296..3433592 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVAN_RS15800 3428717..3429810 - 1094 Protein_3107 IS630 family transposase -
RVAN_RS15810 3431597..3431944 - 348 WP_013419097.1 IS66 family insertion sequence element accessory protein TnpB -
RVAN_RS15815 3431941..3432348 - 408 WP_041787200.1 transposase -
RVAN_RS15825 3433296..3433592 - 297 WP_013420716.1 HigA family addiction module antidote protein Antitoxin
RVAN_RS15830 3433603..3433887 - 285 WP_013420717.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RVAN_RS19295 3434022..3434627 + 606 WP_013420718.1 toll/interleukin-1 receptor domain-containing protein -
RVAN_RS19780 3434646..3435545 - 900 WP_081449501.1 HNH endonuclease -
RVAN_RS15845 3435729..3436232 + 504 WP_210160439.1 DNA mismatch endonuclease Vsr -
RVAN_RS15850 3436355..3436861 + 507 WP_013420722.1 hypothetical protein -
RVAN_RS15855 3437226..3438185 - 960 Protein_3117 IS481 family transposase -
RVAN_RS19785 3438182..3438424 - 243 WP_081449575.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10682.31 Da        Isoelectric Point: 9.9367

>T24968 WP_013420717.1 NC_014664:c3433887-3433603 [Rhodomicrobium vannielii ATCC 17100]
MAIKSFKDDRLAALMSRRVPKGFPSDLIAATRGKLVMLDAARVLDDLRIPPANRLEALKGDRAGQHSIRVNDQFRLCFRW
TAEGPENLEFTDYH

Download         Length: 285 bp

>T24968 NC_014664:c3433887-3433603 [Rhodomicrobium vannielii ATCC 17100]
ATGGCGATCAAAAGCTTCAAGGACGATCGGCTTGCTGCGCTGATGAGCCGCCGCGTGCCCAAGGGCTTTCCATCCGACCT
GATCGCTGCGACGCGGGGCAAGCTTGTCATGCTGGATGCCGCGCGCGTTCTGGACGATCTGCGCATCCCGCCCGCGAACC
GGCTCGAAGCCCTCAAGGGCGACCGCGCCGGCCAGCATTCGATCCGGGTCAACGACCAGTTCCGACTGTGCTTCAGATGG
ACGGCGGAAGGCCCGGAAAACTTGGAGTTTACGGATTATCACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10839.44 Da        Isoelectric Point: 6.4695

>AT24968 WP_013420716.1 NC_014664:c3433592-3433296 [Rhodomicrobium vannielii ATCC 17100]
MTRLPPIHPGEVLREEFLKPFGLSAGAVARAIGVPRTRIERLATEQTELTPDTALRLARFFGTTADFWMNLQARHAIETA
EDALGDTLTQIEPLKRAG

Download         Length: 297 bp

>AT24968 NC_014664:c3433592-3433296 [Rhodomicrobium vannielii ATCC 17100]
ATGACCAGGCTTCCCCCCATTCATCCAGGCGAGGTTCTGCGCGAGGAGTTCCTCAAGCCGTTCGGCCTGTCCGCAGGCGC
TGTCGCGCGCGCCATCGGCGTGCCACGCACTCGTATCGAGCGTCTCGCGACCGAGCAGACGGAACTGACGCCCGACACGG
CACTGCGCCTTGCGCGCTTCTTCGGCACGACGGCGGACTTCTGGATGAATCTGCAAGCCCGCCATGCGATCGAAACCGCC
GAGGACGCCTTGGGCGATACCCTCACGCAGATCGAGCCCTTGAAGCGCGCGGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References