Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1858573..1859135 Replicon chromosome
Accession NZ_CP099883
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag NIZ20_RS08930 Protein ID WP_000605676.1
Coordinates 1858857..1859135 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ20_RS08925 Protein ID WP_000781369.1
Coordinates 1858573..1858857 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS08910 (1856489) 1856489..1857373 + 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIZ20_RS08915 (1857366) 1857366..1858019 + 654 WP_256876185.1 formate dehydrogenase-N subunit gamma -
NIZ20_RS08920 (1858092) 1858092..1858568 + 477 WP_059225294.1 NUDIX domain-containing protein -
NIZ20_RS08925 (1858573) 1858573..1858857 - 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIZ20_RS08930 (1858857) 1858857..1859135 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ20_RS08935 (1859321) 1859321..1860331 - 1011 WP_059225293.1 alcohol dehydrogenase AdhP -
NIZ20_RS08940 (1860465) 1860465..1862162 - 1698 WP_059225292.1 malate dehydrogenase -
NIZ20_RS08945 (1862319) 1862319..1862456 - 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ20_RS08950 (1862714) 1862714..1863145 + 432 WP_059225291.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T249674 WP_000605676.1 NZ_CP099883:c1859135-1858857 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249674 WP_000781369.1 NZ_CP099883:c1858857-1858573 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure

References