Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 626578..627228 Replicon chromosome
Accession NZ_CP099883
Organism Escherichia albertii strain 231_1_NP_B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag NIZ20_RS02955 Protein ID WP_059224977.1
Coordinates 626578..626919 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T5VD61
Locus tag NIZ20_RS02960 Protein ID WP_025237546.1
Coordinates 626929..627228 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ20_RS02935 (622331) 622331..622630 + 300 WP_059224974.1 rod-binding protein -
NIZ20_RS02940 (623188) 623188..624564 + 1377 WP_233991702.1 flagellar hook-associated protein FlgK -
NIZ20_RS02945 (624579) 624579..625508 + 930 WP_025237548.1 flagellar hook-associated protein FlgL -
NIZ20_RS02950 (625525) 625525..626502 + 978 Protein_574 flagellar hook-associated protein -
NIZ20_RS02955 (626578) 626578..626919 + 342 WP_059224977.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ20_RS02960 (626929) 626929..627228 + 300 WP_025237546.1 XRE family transcriptional regulator Antitoxin
NIZ20_RS02965 (627286) 627286..628137 - 852 WP_233991701.1 winged helix-turn-helix domain-containing protein -
NIZ20_RS02970 (628624) 628624..629538 + 915 WP_000949079.1 lateral flagellin LafA -
NIZ20_RS02975 (629649) 629649..629984 + 336 WP_256876143.1 hypothetical protein -
NIZ20_RS02980 (630051) 630051..631367 + 1317 WP_000609691.1 flagellar filament capping protein FliD -
NIZ20_RS02985 (631390) 631390..631782 + 393 WP_000273381.1 flagellar export chaperone FliS -
NIZ20_RS02990 (631787) 631787..632098 + 312 WP_059224980.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13017.79 Da        Isoelectric Point: 5.7334

>T249670 WP_059224977.1 NZ_CP099883:626578-626919 [Escherichia albertii]
MWDVETTETFDNWFDAQTVALKEDLLAAMLILAEYGPQLGRPFADTVNDSQFSNMKELRVQHQGNPVRAFFAFDPARRGI
VLCAGDKTGLNEKKFYRDMIKLADSEYRNHLKK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10962.78 Da        Isoelectric Point: 9.7665

>AT249670 WP_025237546.1 NZ_CP099883:626929-627228 [Escherichia albertii]
MATLKELMAKQSPESQARIAAKVEEMRQTIALHQLREELNISQTEMAAAMGIKQPTLAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPNGKRVAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3T5VD61

References