Detailed information of TA system TA249666

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 248321..248733
• Replicon: chromosome
• Accession: NZ_CP099883
• Organism: Escherichia albertii strain 231_1_NP_B

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: NIZ20_RS01175
• Protein ID: WP_059225014.1
• Coordinates: 248321..248662 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	248657..248733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NIZ20_RS01155 (244695)	244695..245627	+	933	WP_059225013.1	Rpn family recombination-promoting nuclease/putative transposase	-
NIZ20_RS01160 (245780)	245780..245953	-	174	Protein_226	GntR family transcriptional regulator	-
NIZ20_RS01165 (246178)	246178..247054	+	877	Protein_227	DUF262 domain-containing protein	-
NIZ20_RS01170 (247108)	247108..248274	+	1167	WP_077696034.1	DUF1524 domain-containing protein	-
NIZ20_RS01175 (248321)	248321..248662	-	342	WP_059225014.1	endoribonuclease SymE	Toxin
- (248657)	248657..248733	+	77	NuclAT_7	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_7	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_7	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_7	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_8	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_8	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_8	-	Antitoxin
- (248657)	248657..248733	+	77	NuclAT_8	-	Antitoxin
NIZ20_RS01180 (248891)	248891..250186	-	1296	WP_059225015.1	restriction endonuclease subunit S	-
NIZ20_RS01185 (250183)	250183..251772	-	1590	WP_059225016.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12384.20 Da
• Isoelectric Point: 7.8219

>T249666 WP_059225014.1 NZ_CP099883:c248662-248321 [Escherichia albertii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTTQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVITGKQKVA

Nucleotide

• Length: 342 bp

Antitoxin

Nucleotide

• Length: 77 bp

>AT249666 NZ_CP099883:248657-248733 [Escherichia albertii]
AGTCATGATTACTATTCTCCAGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin