Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4016322..4016580 Replicon chromosome
Accession NZ_CP099880
Organism Escherichia albertii strain 233_2_GWG_B

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NIZ21_RS19625 Protein ID WP_000809168.1
Coordinates 4016428..4016580 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4016322..4016379 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ21_RS19610 4012129..4013376 - 1248 WP_059224806.1 hypothetical protein -
NIZ21_RS19615 4013530..4015023 - 1494 WP_059214855.1 sulfatase-like hydrolase/transferase -
NIZ21_RS19620 4015044..4015805 - 762 WP_001276206.1 outer membrane protein OmpK -
- 4016322..4016379 - 58 - - Antitoxin
NIZ21_RS19625 4016428..4016580 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NIZ21_RS19630 4016688..4017818 - 1131 WP_001118445.1 molecular chaperone DnaJ -
NIZ21_RS19635 4017907..4019823 - 1917 WP_000516137.1 molecular chaperone DnaK -
NIZ21_RS19640 4020198..4020602 + 405 WP_000833521.1 DUF2541 family protein -
NIZ21_RS19645 4020629..4021342 + 714 WP_059224803.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T249653 WP_000809168.1 NZ_CP099880:4016428-4016580 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT249653 NZ_CP099880:c4016379-4016322 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References