Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2439059..2439621 Replicon chromosome
Accession NZ_CP099877
Organism Escherichia albertii strain 247_2_EW_B

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIZ22_RS11935 Protein ID WP_000605679.1
Coordinates 2439059..2439337 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ22_RS11940 Protein ID WP_000781369.1
Coordinates 2439337..2439621 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ22_RS11915 (2435039) 2435039..2435470 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIZ22_RS11920 (2435737) 2435737..2435874 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ22_RS11925 (2436031) 2436031..2437728 + 1698 WP_000433442.1 malate dehydrogenase -
NIZ22_RS11930 (2437863) 2437863..2438873 + 1011 WP_000642386.1 alcohol dehydrogenase AdhP -
NIZ22_RS11935 (2439059) 2439059..2439337 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ22_RS11940 (2439337) 2439337..2439621 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIZ22_RS11945 (2439849) 2439849..2440502 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIZ22_RS11950 (2440495) 2440495..2441379 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIZ22_RS11955 (2441392) 2441392..2444439 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249625 WP_000605679.1 NZ_CP099877:2439059-2439337 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249625 WP_000781369.1 NZ_CP099877:2439337-2439621 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References