Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1882368..1882885 Replicon chromosome
Accession NC_014643
Organism Rothia dentocariosa ATCC 17931

Toxin (Protein)


Gene name yoeB Uniprot ID E3H167
Locus tag HMPREF0733_RS08090 Protein ID WP_013398864.1
Coordinates 1882625..1882885 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E3H166
Locus tag HMPREF0733_RS08085 Protein ID WP_013398863.1
Coordinates 1882368..1882622 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0733_RS11180 1879408..1879827 + 420 WP_141744352.1 hypothetical protein -
HMPREF0733_RS08065 1879797..1880492 + 696 WP_013398859.1 hypothetical protein -
HMPREF0733_RS08070 1880507..1880770 + 264 WP_013398860.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HMPREF0733_RS08075 1880839..1881477 - 639 WP_013398861.1 hypothetical protein -
HMPREF0733_RS08080 1881597..1882226 - 630 WP_041321736.1 hypothetical protein -
HMPREF0733_RS08085 1882368..1882622 + 255 WP_013398863.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
HMPREF0733_RS08090 1882625..1882885 + 261 WP_013398864.1 Txe/YoeB family addiction module toxin Toxin
HMPREF0733_RS08095 1882975..1887414 - 4440 WP_013398865.1 ATP-dependent RNA helicase HrpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10304.69 Da        Isoelectric Point: 8.9265

>T24962 WP_013398864.1 NC_014643:1882625-1882885 [Rothia dentocariosa ATCC 17931]
VRIIFDDSAWSDYLWWQVQDRKVLKRINLLIKDVERNGNEGIGKPEALRHQFSGWWSRRITDEHRLVYKLTDDSIVIASC
RYHYGA

Download         Length: 261 bp

>T24962 NC_014643:1882625-1882885 [Rothia dentocariosa ATCC 17931]
GTGAGAATTATTTTTGACGATTCAGCATGGAGCGACTATCTCTGGTGGCAGGTGCAAGATCGGAAGGTTCTCAAGCGCAT
TAATCTACTGATCAAAGATGTTGAGCGAAATGGTAATGAAGGTATAGGGAAGCCTGAAGCTCTCAGACATCAATTTTCAG
GCTGGTGGTCACGCAGAATTACTGATGAACACCGTCTCGTATACAAGCTTACTGATGACTCTATTGTCATAGCTTCATGC
CGATATCACTATGGCGCGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9618.77 Da        Isoelectric Point: 4.7157

>AT24962 WP_013398863.1 NC_014643:1882368-1882622 [Rothia dentocariosa ATCC 17931]
MKTMSYTESRARYAEVLDHVEDHREEVIITRAGHEPAVILSLSEYESLQETAYLMRSPANARRLMESISRLEAGLGSEHQ
LVEE

Download         Length: 255 bp

>AT24962 NC_014643:1882368-1882622 [Rothia dentocariosa ATCC 17931]
ATGAAAACCATGTCTTACACCGAGTCGCGGGCTCGGTATGCTGAAGTACTTGACCACGTTGAAGATCACCGTGAAGAGGT
TATTATTACACGTGCCGGGCATGAACCGGCAGTCATTCTCTCATTGTCTGAGTACGAATCTCTTCAAGAGACTGCCTACC
TCATGCGTTCCCCGGCTAATGCACGTCGTCTTATGGAATCCATCTCCCGTCTTGAAGCTGGTCTTGGGTCTGAGCATCAG
CTGGTTGAGGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3H167

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1QSL1

References