Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3917619..3917877 Replicon chromosome
Accession NZ_CP099874
Organism Escherichia albertii strain 251_2_EW_B

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag NIZ23_RS19090 Protein ID WP_000809168.1
Coordinates 3917725..3917877 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3917619..3917676 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ23_RS19075 3913426..3914673 - 1248 WP_059235056.1 hypothetical protein -
NIZ23_RS19080 3914827..3916320 - 1494 WP_256875787.1 sulfatase-like hydrolase/transferase -
NIZ23_RS19085 3916341..3917102 - 762 WP_001276206.1 outer membrane protein OmpK -
- 3917619..3917676 - 58 - - Antitoxin
NIZ23_RS19090 3917725..3917877 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
NIZ23_RS19095 3917985..3919115 - 1131 WP_001118445.1 molecular chaperone DnaJ -
NIZ23_RS19100 3919204..3921120 - 1917 WP_000516135.1 molecular chaperone DnaK -
NIZ23_RS19105 3921495..3921899 + 405 WP_000833521.1 DUF2541 family protein -
NIZ23_RS19110 3921926..3922639 + 714 WP_001102345.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T249602 WP_000809168.1 NZ_CP099874:3917725-3917877 [Escherichia albertii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT249602 NZ_CP099874:c3917676-3917619 [Escherichia albertii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References