Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2439264..2439826 Replicon chromosome
Accession NZ_CP099874
Organism Escherichia albertii strain 251_2_EW_B

Toxin (Protein)


Gene name higB Uniprot ID A0A7U8ZNU8
Locus tag NIZ23_RS11940 Protein ID WP_000605679.1
Coordinates 2439264..2439542 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NIZ23_RS11945 Protein ID WP_000781369.1
Coordinates 2439542..2439826 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NIZ23_RS11920 (2435244) 2435244..2435675 - 432 WP_059225291.1 peroxiredoxin OsmC -
NIZ23_RS11925 (2435942) 2435942..2436079 + 138 WP_000841563.1 stationary-phase-induced ribosome-associated protein -
NIZ23_RS11930 (2436236) 2436236..2437933 + 1698 WP_000433442.1 malate dehydrogenase -
NIZ23_RS11935 (2438068) 2438068..2439078 + 1011 WP_000642386.1 alcohol dehydrogenase AdhP -
NIZ23_RS11940 (2439264) 2439264..2439542 + 279 WP_000605679.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NIZ23_RS11945 (2439542) 2439542..2439826 + 285 WP_000781369.1 HigA family addiction module antitoxin Antitoxin
NIZ23_RS11950 (2440054) 2440054..2440707 - 654 WP_000045636.1 formate dehydrogenase-N subunit gamma -
NIZ23_RS11955 (2440700) 2440700..2441584 - 885 WP_001240583.1 formate dehydrogenase N subunit beta -
NIZ23_RS11960 (2441597) 2441597..2444644 - 3048 WP_077776584.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10533.10 Da        Isoelectric Point: 7.3995

>T249600 WP_000605679.1 NZ_CP099874:2439264-2439542 [Escherichia albertii]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASSLVDIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10371.06 Da        Isoelectric Point: 8.8567

>AT249600 WP_000781369.1 NZ_CP099874:2439542-2439826 [Escherichia albertii]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVAQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U8ZNU8

Antitoxin

Source ID Structure

References